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Sjogren's syndrome: Can it cause recurrent UTIs?

Since being diagnosed with Sjogren's syndrome last year, I've had three urinary tract infections. Is there any evidence that Sjogren's syndrome causes recurrent UTIs?

- Patti / Illinois

Mayo Clinic rheumatologist April Chang-Miller, M.D., and colleagues answer select questions from readers.

Answer

Sjogren's syndrome is an autoimmune disorder in which the moisture-secreting glands of the eyes and mouth became inflamed, producing fewer tears and less saliva. There's no evidence that Sjogren's syndrome causes urinary tract infections (UTIs). However, Sjogren's syndrome may be associated with other conditions that share similar symptoms.

For women, Sjogren's syndrome can cause vaginal dryness — which may result in discomfort during sexual intercourse (dyspareunia) and an increase in the risk of bacterial and fungal vaginal infections. Painful urination, a common symptom of UTIs, also can occur with vaginal infections.

Also, several studies report a connection between Sjogren's syndrome and interstitial cystitis — a condition characterized by increased urinary frequency, urgency and discomfort. In fact, in one 2003 study, 28 percent of people who had interstitial cystitis also had Sjogren's syndrome. Treatment of interstitial cystitis varies, possibly including medication, nerve stimulation or, rarely, surgery.

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Dec 2, 2008