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  • With Mayo Clinic medical oncologist

    Timothy Moynihan, M.D.

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Question

Pancreatic cancer treatment: Why is it so challenging?

Why is pancreatic cancer so difficult to treat?

Answer

from Timothy Moynihan, M.D.

Pancreatic cancer is one of the deadliest cancers. Even with aggressive treatment, the prognosis is poor. Various factors stack the odds against successful pancreatic cancer treatment.

For example:

  • Early detection is uncommon. Few pancreatic cancers are found in the early stages of the disease, when the cancerous cells can be surgically removed. Signs and symptoms of pancreatic cancer — such as pain in the upper abdomen, yellow skin and eyes, and weight loss — don't typically occur until the disease is advanced.
  • Pancreatic cancer tends to spread quickly. Pancreatic cancer often spreads to nearby organs — including the liver, gallbladder and intestines — early in the course of the disease.
  • Recurrence is likely. Even after surgical removal, pancreatic cancer often recurs.

In addition, pancreatic cancer tends to be relatively resistant to many chemotherapy drugs. However, several newer drugs show promise in increasing the response rate to pancreatic cancer treatment.

References
  1. Steer ML. Clinical manifestations, diagnosis, and surgical staging of exocrine pancreatic cancer. http://www.uptodate.com/home/index.html. Accessed Oct. 2, 2008.
  2. Ryan DP, et al. Management of locally advanced pancreatic exocrine cancer. http://www.uptodate.com/home/index.html. Accessed Oct. 2, 2008.
  3. Ryan DP. Chemotherapy for advanced pancreatic adenocarcinoma. http://www.uptodate.com/home/index.html. Accessed Oct. 2, 2008.

AN01505

Jan. 6, 2009

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