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Fish oil supplements: Can they treat depression?

Is there any benefit to taking fish oil supplements for depression?

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Mayo Clinic psychiatrist Daniel Hall-Flavin, M.D., and colleagues answer select questions from readers.

Answer

A number of studies suggest that fish oil supplements may be an effective add-on (adjuvant) therapy for depression. In fact, some studies suggest that fish oil supplements may be as effective as prescription antidepressant medication — but the two in combination are more effective than either taken alone. However, more research is needed to confirm these results.

Fish oil is a good source of omega-3 fatty acids. Fatty acids have been shown to play an important role in brain function as well as normal growth and development. Some research has suggested that people who have depression have low blood levels of eicosapentaenoic acid (EPA), a fatty acid found in fish oil.

At this time, it's probably premature to make a strong recommendation for or against fish oil supplements as a treatment for depression. Consult your doctor before starting any new dietary or herbal supplement to treat depression, especially if you take other medications.

Another way to get more omega-3 fatty acids, including EPA, is to simply eat more fish. Try salmon, mackerel and tuna. Other dietary sources of omega-3 fatty acids include flaxseed, canola oil, soybeans, pumpkin seeds and walnuts.

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Oct 15, 2008