- With Mayo Clinic psychiatrist
Daniel K. Hall-Flavin, M.D.
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Daniel K. Hall-Flavin, M.D.
Daniel K. Hall-Flavin, M.D.
Dr. Daniel Hall-Flavin, board certified in general psychiatry and addiction psychiatry, is a St. Louis native looking to the Internet as a way to help people improve their health and be more active participants in their own health care by learning from Mayo Clinic's experts.
Dr. Hall-Flavin has been a member of the faculties of Cornell University Medical College, New York Medical College, and The George Washington University Medical School before joining the Mayo Clinic staff in 1996. He has special interests in adult psychiatry, addiction psychiatry, and psychogenomics. He has served as medical director of the National Council on Alcoholism and Drug Dependence from 1986 to 1999.
"With the advent of the genomics and proteomics revolution and the pace of advances in medicine, informed collaborative relationships between knowledgeable, capable health professionals and informed, proactive individuals and their families are more vital than ever," he said.
"I'm optimistic that our Internet health education activities will contribute to ever-improving health outcomes for all who participate and apply what is learned."
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Question
Antidepressants and weight gain: What causes it?
Can antidepressants cause weight gain?
Answer
from Daniel K. Hall-Flavin, M.D.
The exact relationship between antidepressants and weight gain isn't clear, but weight gain is a reported side effect of nearly all antidepressants.
Certain antidepressants are more likely to cause weight gain than are others. For example, tricyclic antidepressants and monoamine oxidase inhibitors (MAOIs) are more likely to be associated with weight gain than are selective serotonin reuptake inhibitors (SSRIs). The exception to this may be long-term use of paroxetine (Paxil) — an SSRI that's more likely to cause weight gain than are other SSRIs.
It's not possible to predict who's most likely to gain weight from taking antidepressants. However, recent research has shown that people who gain weight within about the first week of starting antidepressant treatment are more likely to have significant weight gain from the medication over an extended period of time.
It's important to remember that association is not the same as causation. There are many factors that can work together to contribute to weight gain during antidepressant therapy. Some people lose weight as part of their depression. In turn, an improved appetite associated with improved mood may result in increased weight. Overeating as a result of depression also can cause weight gain. In addition, some medical conditions that mimic depression — such as underactive thyroid (hypothyroidism) — may cause weight gain.
If you gain weight after starting antidepressant treatment, discuss your concerns with your doctor. He or she can determine the likely cause of weight gain. If your antidepressant seems to be the culprit, it may help to adjust the dose or switch medications.
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